Parp Inhibitor Breast Cancer Side Effects

Introduction poly adp ribose polymerase parp inhibitors are a class of oral anticancer medications that have the most evidence for use in patients with inherited germline mutations.

Parp inhibitor breast cancer side effects.

They are also in trials as a treatment for other types of cancer. Common parp inhibitor side effects. Parp inhibitors for treating breast cancer lynparza and talzenna have received fda approval for treating metastatic breast cancer caused by a brca mutation. Lung and airway infection or inflammation.

We spoke to dr. Parp inhibitors are a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase parp. In general parp inhibitors cause fewer and less serious side effects than some other cancer treatments. Ursula matulonis chief of gynecologic oncology at the dana farber cancer institute to learn more about these potential side effects.

See below for a comprehensive list of adverse effects. Side effects of parp inhibitors. Here two oncology pharmacists discuss the side effects of parp inhibitor treatment and how to prevent and treat nausea and vomiting in this patient population. And low white blood cell counts.

Several forms of cancer are more dependent on parp than regular cells making parp parp1 parp2 etc an attractive target for cancer therapy parp inhibitors appear to improve progression free. Headache they can also cause low red blood cell counts called anemia which can lead to fatigue and other problems. The side effects of parp inhibitors can usually be controlled or reduced and those described here will not affect everyone. The most common side effects of parp inhibitors are.

Parp inhibitors are a type of targeted cancer drug. They are developed for multiple indications including the treatment of heritable cancers. They are a treatment for some women with ovarian cancer. Everyone reacts differently to drugs and some people have more side effects than others.

It helps damaged cells to repair themselves. Based on clinical trial results the national comprehensive cancer network nccn added lynparza as a preferred treatment for people with advanced breast cancer and a brca mutation. Like any drugs parp inhibitors can cause side effects and different ones will have varying effects. Side effects requiring immediate medical attention.

Upper respiratory tract infection anemia decreased hemoglobin increased mcv increased serum creatinine nasopharyngitis nausea pharyngitis vomiting cough and dyspnea.